环境空气、柴油发动机和汽油发动机颗粒提取物的极性部分的化学分析和生物学测试。
Chemical analysis and biological testing of a polar fraction of ambient air, diesel engine, and gasoline engine particulate extracts.
作者信息
Strandell M, Zakrisson S, Alsberg T, Westerholm R, Winquist L, Rannug U
机构信息
Laboratory for Analytical Environmental Chemistry, University of Stockholm, Solna, Sweden.
出版信息
Environ Health Perspect. 1994 Oct;102 Suppl 4(Suppl 4):85-92. doi: 10.1289/ehp.94102s485.
Abstract
Extracts of gasoline and diesel vehicle exhaust and ambient air particles were fractionated into five fractions according to polarity on a silica gel column. Two medium polar fractions showing high genotoxic activity in the Ames test were further subfractionated, using normal-phase high-performance liquid chromatography. Chemical analyses were performed by means of gas chromatography combined with mass spectrometry and flame ionization and detection. The crude extracts, fractions, and subfractions were assayed with the Ames test, with and without S9, and the most abundant compounds in the subfractions are reported.
摘要
将汽油和柴油车辆尾气及环境空气颗粒的提取物在硅胶柱上根据极性分为五个馏分。在艾姆斯试验中显示出高遗传毒性活性的两个中等极性馏分，使用正相高效液相色谱法进一步细分。通过气相色谱结合质谱、火焰离子化和检测进行化学分析。对粗提取物、馏分和细分馏分进行有或无S9的艾姆斯试验，并报告细分馏分中含量最高的化合物。
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