López-Sañudo S, Arilla E
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Alcalá, Madrid, Spain.
Neurosci Lett. 1994 Aug 15;177(1-2):107-10. doi: 10.1016/0304-3940(94)90056-6.
The administration of an i.p. dose of phenylephrine (2 mg/kg) increased the number of [125I]Tyr11-somatostatin ([125I]Tyr11-SS) receptors and decreased their apparent affinity in rat hippocampal membranes 7 h after its injection. Prazosin (20 mg/kg, i.p.) administered 1 h before phenylephrine reversed effects of the latter on SS binding. Prazosin alone decreased the number of SS receptors without changing the affinity. The addition of phenylephrine or prazosin (10(-5) M) to the incubation medium did not change the SS binding characteristics. The present results support the notion that the alpha 1-adrenergic system regulates the binding of SS to its specific receptors in rat hippocampus.
腹腔注射苯肾上腺素（2毫克/千克）后7小时，大鼠海马膜中[125I]酪氨酸11-生长抑素（[125I]Tyr11-SS）受体数量增加，其表观亲和力降低。在注射苯肾上腺素前1小时腹腔注射哌唑嗪（20毫克/千克）可逆转后者对SS结合的影响。单独使用哌唑嗪可减少SS受体数量，但不改变亲和力。向孵育培养基中添加苯肾上腺素或哌唑嗪（10^(-5) M）不会改变SS结合特性。目前的结果支持α1-肾上腺素能系统调节大鼠海马中SS与其特异性受体结合的观点。
