Eto H, Toriyama K, Itakura H
Department of Pathology, Nagasaki University, Japan.
Southeast Asian J Trop Med Public Health. 1994 Mar;25(1):88-92.
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in Japan as well as Southeast Asia and Africa. On 89 patients with HCC in the Nagasaki City area were performed serological examinations and histopathological studies. The number of HBsAg positive and anti-HCV positive was three (3%), HBsAg positive and anti-HCV negative 21 (24%), HBsAg negative and anti-HCV positive 58 (65%) and HBsAg negative and anti-HCV negative seven (8%). These results strongly suggest that HCV infection is a more important factor in the development of HCC than HBV infection. The HBsAg negative and anti-HCV positive group showed a higher mean age and a higher male to female ratio than the HBsAg positive and anti-HCV negative group. Histological examinations showed no differences between these two groups. In addition, all cases were complicated with chronic hepatitis (CH) or liver cirrhosis (LC) in adjacent liver tissue. These findings suggest that CH and LC seem to play an important role in the pathogenesis of HCC.
肝细胞癌（HCC）是日本以及东南亚和非洲最常见的癌症之一。对长崎市地区的89例肝癌患者进行了血清学检查和组织病理学研究。HBsAg阳性且抗HCV阳性的有3例（3%），HBsAg阳性且抗HCV阴性的有21例（24%），HBsAg阴性且抗HCV阳性的有58例（65%），HBsAg阴性且抗HCV阴性的有7例（8%）。这些结果有力地表明，丙肝病毒感染在肝癌发生中比乙肝病毒感染是更重要的因素。HBsAg阴性且抗HCV阳性组比HBsAg阳性且抗HCV阴性组显示出更高的平均年龄和更高的男女比例。组织学检查显示这两组之间没有差异。此外，所有病例在相邻肝组织中均合并有慢性肝炎（CH）或肝硬化（LC）。这些发现表明，CH和LC似乎在HCC的发病机制中起重要作用。
