Pramoolsinsap C, Sumalnop K, Busagorn N, Kurathong S
Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1992 Mar;23(1):6-11.
The prevalences of serological markers of hepatitis B virus (HBV) and antibody to hepatitis C virus (anti-HCV) were determined in 168 patients (135 males and 33 females), aged 19-79 years (mean = 50.8) in Thailand. Of these, 33 had chronic persistent hepatitis, 35 chronic active hepatitis, 50 cirrhosis and 50 hepatocellular carcinoma (HCC). Seromarkers for either HBV or anti-HCV or both were detected in 140 (83.3%), 3 (1.8%) and 18 (10.7%) patients, respectively, but 7 (4.2%) were sero-negative for both viruses. The overall prevalence of anti-HCV was 12.5% but was significantly lower in HCC (2%) compared to the other 3 groups of liver disease (12-21.5%, p less than or equal to 0.05) and in HBsAg positive (5%) compared to HBsAg negative (30%) patients (p less than 0.001). After 0.5-9 years follow-up of all anti-HCV positive patients, 2 died and another 6 had progressive liver disease. The prevalence of coexistent HBV seromarkers was similar in patients with a progressive (87.5%) and a stable clinical course (92.3%) (p = 0.62). A higher proportion of the anti-HCV-positive patients with a progressive course had a history of blood transfusion [75.0% vs 46.1% (p = 0.20)]. These findings suggest that HBV is the most important etiologic virus associated with chronic liver disease and HCC in Thailand, but HCV may play a role particularly in HBsAg-negative patients.
在泰国，对168名年龄在19至79岁（平均50.8岁）的患者（135名男性和33名女性）进行了乙肝病毒（HBV）血清学标志物和丙肝病毒抗体（抗-HCV）检测。其中，33例为慢性持续性肝炎，35例为慢性活动性肝炎，50例为肝硬化，50例为肝细胞癌（HCC）。分别在140例（83.3%）、3例（1.8%）和18例（10.7%）患者中检测到HBV或抗-HCV或两者的血清学标志物，但7例（4.2%）患者两种病毒血清学检测均为阴性。抗-HCV的总体患病率为12.5%，但与其他3组肝病（12 - 21.5%，p≤0.05）相比，HCC患者中的患病率显著较低（2%），与HBsAg阴性患者（30%）相比，HBsAg阳性患者中的患病率（5%）也显著较低（p＜0.001）。对所有抗-HCV阳性患者进行0.5至9年的随访后，2例死亡，另外6例出现进行性肝病。在病情进展（87.5%）和临床病程稳定（92.3%）的患者中并存HBV血清学标志物的患病率相似（p = 0.62）。病情进展的抗-HCV阳性患者中有输血史的比例更高[75.0%对46.1%（p = 0.20）]。这些发现表明，HBV是泰国慢性肝病和HCC最重要的致病病毒，但HCV可能尤其在HBsAg阴性患者中起作用。
