Wilton L J, Temple-Smith P D, Baker H W, de Kretser D M
Monash University, Medical Research Centre, Victoria, Australia.
Fertil Steril. 1988 Jun;49(6):1052-8. doi: 10.1016/s0015-0282(16)59960-9.
Four patients with persistent oligospermia and necrospermia were found to have severely degenerated sperm in the ejaculate. However, in those examined, testicular sperm were ultrastructurally normal, indicating that sperm degeneration and death was occurring during epididymal passage or storage or both or upon mixing with the seminal plasma at ejaculation. Seminal plasma was found to be nontoxic to normal donor sperm. In three patients, frequent ejaculation (two ejaculates per day for 4 or 5 days) was used to deplete epididymal sperm reserves and reduce the period spent in the epididymis. This resulted in a threefold to sevenfold increase in percentage of motile sperm in the ejaculate and a similar increase in sperm motility index. The authors propose the term "epididymal necrospermia" to describe this previously undefined type of male infertility.
四名持续性少精子症和死精子症患者的射精精液中发现精子严重退化。然而，在接受检查的患者中，睾丸精子的超微结构正常，这表明精子退化和死亡发生在附睾运输或储存过程中，或两者皆有，或在射精时与精浆混合时发生。研究发现精浆对正常供体精子无毒。在三名患者中，采用频繁射精（每天射精两次，持续4或5天）来耗尽附睾精子储备并缩短精子在附睾中的停留时间。这使得射精精液中活动精子的百分比增加了三倍至七倍，精子活力指数也有类似增加。作者提出用“附睾性死精子症”这一术语来描述这种先前未定义的男性不育类型。
