细胞角蛋白片段相关抗原（CYFRA）检测在肺癌诊断中的临床应用：血清细胞角蛋白片段的测定
Clinical usefulness of CYFRA assay in diagnosing lung cancer: measurement of serum cytokeratin fragment.
作者信息
Sugama Y, Kitamura S, Kawai T, Ohkubo A, Hasegawa S, Kuriyama T, Kato H, Fukuoka M, Ohkawa J
机构信息
Department of Pulmonary Medicine, Jichi Medical School, Tochigi.
出版信息
Jpn J Cancer Res. 1994 Nov;85(11):1178-84. doi: 10.1111/j.1349-7006.1994.tb02925.x.
We evaluated the diagnostic usefulness of measurement of the soluble cytokeratin 19 fragment, a new tumor marker, in 391 patients with lung cancer and in 424 patients with benign lung diseases. Serum concentrations of cytokeratin 19 fragment were measured by a sandwich ELISA (CYFRA). The cut-off value was defined as 3.5 ng/ml, which is associated with a specificity of 85% for benign lung diseases. CYFRA had a high sensitivity (57.5%) in all subjects with lung carcinoma, and had a higher sensitivity for squamous cell carcinoma (73.1%, n = 141) than squamous cell carcinoma-related antigen (61.0%). CYFRA was associated with a relatively high sensitivity (42.1%) in early-stage squamous cell carcinoma (stage I, based on the classification of the Japan Lung Cancer Society), but the CYFRA titer was higher in advanced squamous cell carcinoma than in early-stage squamous cell carcinoma. Our findings suggest that CYFRA is potentially useful for diagnosis and monitoring of lung carcinoma, especially for squamous cell carcinoma.
我们评估了新型肿瘤标志物可溶性细胞角蛋白19片段检测在391例肺癌患者和424例良性肺病患者中的诊断价值。采用夹心酶联免疫吸附测定法（CYFRA）检测细胞角蛋白19片段的血清浓度。临界值设定为3.5 ng/ml，该值对于良性肺病的特异性为85%。CYFRA在所有肺癌患者中具有较高的敏感性（57.5%），对鳞状细胞癌的敏感性（73.1%，n = 141）高于鳞状细胞癌相关抗原（61.0%）。CYFRA在早期鳞状细胞癌（根据日本肺癌学会的分类为I期）中具有相对较高的敏感性（42.1%），但晚期鳞状细胞癌的CYFRA滴度高于早期鳞状细胞癌。我们的研究结果表明，CYFRA可能对肺癌尤其是鳞状细胞癌的诊断和监测有用。
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