Bhatti A S, Khan H H
Department of Pharmacology and Therapeutics, Allama Iqbal Medical College, Lahore.
J Pak Med Assoc. 1994 Nov;44(11):261-4.
The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1.5-2 kg. Pretreatment of animals with aspirin (50 mg/kg i/v) suppressed all arrhythmias during ischaemia. Low dose of aspirin (12.5 mg/kg i/v) produced no mortality. Indomethacin (2.5 mg/kg) was unable to control ischaemia and reperfusion-induced ventricular arrhythmias. However, higher doses of indomethacin (50 mg/kg) suppressed ischaemia-induced arrhythmias to some extent but the mortality rate was increased (37%). Fragment of ventricular fibrillation was zero during ischaemia after treatment with aspirin and indomethacin but reperfusion-induced ventricular fibrillation was not controlled by any of these drugs. Aspirin (12.5 mg/kg, 50 mg/kg) and indomethacin (2.5 mg/kg) significantly suppressed ischaemia--induced tachyarrhythmias while reperfusion induced tachyarrhythmias were suppressed only by aspirin. There was no significant effect on the mean arterial pressure after these drug treatments.
在50只体重为1.5 - 2千克的雄性兔子身上，评估了阿司匹林和吲哚美辛对结扎（缺血）和松开结扎（再灌注）左冠状动脉回旋支所产生的室性心律失常的影响。用阿司匹林（50毫克/千克，静脉注射）对动物进行预处理可抑制缺血期间的所有心律失常。低剂量阿司匹林（12.5毫克/千克，静脉注射）未导致死亡。吲哚美辛（2.5毫克/千克）无法控制缺血和再灌注诱导的室性心律失常。然而，较高剂量的吲哚美辛（50毫克/千克）在一定程度上抑制了缺血诱导的心律失常，但死亡率增加（37%）。在用阿司匹林和吲哚美辛治疗后，缺血期间心室颤动片段为零，但这些药物均无法控制再灌注诱导的心室颤动。阿司匹林（12.5毫克/千克、50毫克/千克）和吲哚美辛（2.5毫克/千克）显著抑制缺血诱导的快速性心律失常，而只有阿司匹林能抑制再灌注诱导的快速性心律失常。这些药物治疗后对平均动脉压无显著影响。
