Auerbach W, Auerbach R
Center for Developmental Biology, University of Wisconsin, Madison 53706.
Pharmacol Ther. 1994 Sep;63(3):265-311. doi: 10.1016/0163-7258(94)90027-2.
In this review we discuss the concept of anti-angiogenesis, which is the inhibition of neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on various elements of the angiogenic process, including induction of vascular discontinuity, endothelial cell movement, endothelial cell proliferation, and three-dimensional restructuring of patent vessels. An effort is made to place the many different approaches to anti-angiogenesis research into a comprehensible structure, in order to identify problems of evaluation and interpretation, thereby providing a clearer basis for determining promising and needed directions for further investigation.
在本综述中，我们讨论抗血管生成的概念，即抑制新血管形成。抗血管生成药物是从它们对血管生成过程中各个要素的影响这一角度来考量的，这些要素包括诱导血管中断、内皮细胞移动、内皮细胞增殖以及成熟血管的三维重构。我们致力于将抗血管生成研究的众多不同方法整合到一个易于理解的框架中，以便识别评估和解释方面的问题，从而为确定有前景且有必要进一步研究的方向提供更清晰的依据。
