Tonk V S, Wilson K S, Timmons C F, Schneider N R
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
Genes Chromosomes Cancer. 1994 Nov;11(3):199-202. doi: 10.1002/gcc.2870110309.
Short-term cultures of three hepatoblastomas were analyzed cytogenetically. Trisomy 2, trisomy 20, and a deletion of 17p were found as the sole abnormalities, yielding the karyotypes 47,XY, + 2; 47,XX, + 20; and 46,XX,del(17)(p12)/46,XX. This is the first reported case of deletion of 17p as the sole chromosomal abnormality in a hepatoblastoma and the first reported case of trisomy 20 without double minute chromosomes as a sole chromosomal abnormality in hepatoblastoma.
对三例肝母细胞瘤的短期培养物进行了细胞遗传学分析。发现2号染色体三体、20号染色体三体和17p缺失是唯一的异常情况，其核型分别为47,XY, + 2；47,XX, + 20；以及46,XX,del(17)(p12)/46,XX。这是首次报道肝母细胞瘤中17p缺失作为唯一染色体异常的病例，也是首次报道20号染色体三体且无双微体作为肝母细胞瘤唯一染色体异常的病例。
