Pantev C, Bertrand O, Eulitz C, Verkindt C, Hampson S, Schuierer G, Elbert T
Center of Biomagnetism, Institute of Experimental Audiology University of Münster, Germany.
Electroencephalogr Clin Neurophysiol. 1995 Jan;94(1):26-40. doi: 10.1016/0013-4694(94)00209-4.
This paper presents data concerning auditory evoked responses in the middle latency range (wave Pam/Pa) and slow latency range (wave N1m/N1) recorded from 12 subjects. It is the first group study to report multi-channel data of both MEG and EEG recordings from the human auditory cortex. The experimental procedure involved potential and current density topographical brain mapping as well as magnetic and electric source analysis. Responses were compared for the following 3 stimulus frequencies: 500, 1000 and 4000 Hz. It was found that two areas of the auditory cortex showed mirrored tonotopic organization; one area, the source of N1m/N1 wave, exhibited higher frequencies at progressively deeper locations, while the second area, the source of the Pam/Pa wave, exhibited higher frequencies at progressively more superficial locations. The Pa tonotopic map was located in the primary auditory cortex anterior to the N1m/N1 mirror map. It is likely that N1m/N1 results from activation of secondary auditory areas. The location of the Pa map in A1, and its N1 mirror image in secondary auditory areas is in agreement with observations from animal studies.
本文展示了从12名受试者记录到的中潜伏期范围（波Pam/Pa）和慢潜伏期范围（波N1m/N1）的听觉诱发反应数据。这是第一项报告来自人类听觉皮层的脑磁图（MEG）和脑电图（EEG）记录的多通道数据的群体研究。实验过程包括电位和电流密度地形图绘制以及磁源和电源分析。对以下三种刺激频率的反应进行了比较：500、1000和4000赫兹。研究发现，听觉皮层的两个区域呈现出镜像式的音频拓扑组织；一个区域，即N1m/N1波的来源，在位置逐渐变深的地方表现出更高的频率，而第二个区域，即Pam/Pa波的来源，则在位置逐渐变浅的地方表现出更高的频率。Pa音频拓扑图位于N1m/N1镜像图前方的初级听觉皮层。N1m/N1可能是由二级听觉区域的激活产生的。Pa图在初级听觉皮层（A1）中的位置及其在二级听觉区域中的N1镜像与动物研究的观察结果一致。
