Hustin J, Philippe E, Teisner B, Grudzinskas J G
Institut de Morphologie Pathologique, Loverval, Belgium.
Placenta. 1994 Oct;15(7):701-8. doi: 10.1016/0143-4004(94)90032-9.
Insulin-like growth factor binding protein-1 (IGFBP-1) [also known as placental protein 12(PP12)] and placental protein 14 (PP14) have been identified by specific immunostaining in early pregnancy specimens obtained 13-35 days of gestation. PP12 was evident in a discrete number of stromal decidual cells at the deciduotrophoblastic interface and under the endometrial surface epithelium. These cells did not have the rounded appearance of classic decidual cells but most often displayed cytoplasmic expansions. Staining for PP14 was strictly localized to the glandular epithelium of the endometrium. Implantation of the conceptus may be an important mechanism in the early expression of PP12 but not PP14.
胰岛素样生长因子结合蛋白-1（IGFBP-1）[也称为胎盘蛋白12（PP12）]和胎盘蛋白14（PP14）已通过对妊娠13 - 35天获得的早期妊娠标本进行特异性免疫染色得以鉴定。PP12在蜕膜滋养层界面和子宫内膜表面上皮下方的离散数量的基质蜕膜细胞中明显可见。这些细胞没有典型蜕膜细胞的圆形外观，而是最常表现出细胞质扩张。PP14的染色严格局限于子宫内膜的腺上皮。孕体着床可能是PP12早期表达的重要机制，但不是PP14早期表达的重要机制。
