Liu D, Xin Y L, Ge B, Zhao F, Zhso H
Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing.
Eur J Surg Suppl. 1994(574):71-2.
Experimental and clinical studies have been performed to explore the potential benefits of electrochemical therapy (ECT) in oesophageal cancer. In a dog experiment, the oesophageal injury induced by ECT was evaluated. The provision of 7.5 volts (V) and 25-100 coulomb (C) was associated with a slight injury of the mucosa, which was completely healed after two weeks. Ten patients with oesophageal stenosis were treated with ECT (4.5-5.5 V, 20-50 mA and 85-180 C). In all patients there was a significant dilatation of the stenotic area and the patients could eat a normal diet after three to four weeks. The clinical effectiveness in 35 patients treated with ECT for inoperable oesophagela carcinoma was found to be satisfactory. Complete and partial response was obtained in 15 cases (42.8%), and dysphagia was relieved for five to 13 months. In conclusion, oesophageal cancer may be successfully treated with a specially designed electrode and a specified dosage of electricity.
已经开展了实验研究和临床研究，以探索电化学疗法（ECT）在食管癌治疗中的潜在益处。在一项犬类实验中，评估了ECT所致的食管损伤。施加7.5伏（V）电压和25 - 100库仑（C）电量会导致黏膜轻度损伤，两周后损伤完全愈合。对10例食管狭窄患者进行了ECT治疗（4.5 - 5.5 V，20 - 50毫安（mA），85 - 180 C）。所有患者狭窄部位均出现明显扩张，三到四周后患者能够正常饮食。对35例无法手术的食管癌患者进行ECT治疗，临床疗效令人满意。15例（42.8%）获得完全缓解和部分缓解，吞咽困难缓解了5至13个月。总之，使用专门设计的电极和特定剂量的电流可以成功治疗食管癌。
