Smit B J, Boer K, van Huis A M, Lie-A-Ling I S, Schmidt S C
Academic Medical Center, University of Amsterdam, The Netherlands.
Acta Paediatr Suppl. 1994 Nov;404:32-5. doi: 10.1111/j.1651-2227.1994.tb13381.x.
To study the effects of cocaine use in pregnancy in Amsterdam, clinical data on cocaine-using pregnant women (n = 21) and their offspring (n = 23) were obtained retrospectively (1987-1994) at the Academic Medical Center, Amsterdam. Infants exposed to cocaine had a median gestational age of 39 weeks and a median birth weight of 3090 g. There were six preterm infants, two small-for-gestational-age infants and five infants with a small head circumference. Three infants had a congenital malformation. One infant (Potter's syndrome) died shortly before birth. One infant had congenital syphilis, four had intracerebral abnormalities on ultrasound and four had abnormal neurologic symptoms in the neonatal period. One infant died after 21 days of life. At follow-up four infants showed abnormal development. In 12 of the 23 infants (52%), one or more possible effects of cocaine were found.
为研究阿姆斯特丹孕期使用可卡因的影响，于1987年至1994年在阿姆斯特丹学术医疗中心对使用可卡因的孕妇（n = 21）及其后代（n = 23）的临床数据进行了回顾性收集。暴露于可卡因的婴儿中位孕周为39周，中位出生体重为3090克。有6名早产婴儿、2名小于胎龄儿和5名头围较小的婴儿。3名婴儿有先天性畸形。1名婴儿（波特综合征）在出生前不久死亡。1名婴儿患有先天性梅毒，4名婴儿超声检查显示脑内异常，4名婴儿在新生儿期有异常神经症状。1名婴儿出生21天后死亡。随访时，4名婴儿发育异常。在23名婴儿中的12名（52%）发现了一种或多种可卡因可能产生的影响。
