van Huis Marian, van Kempen Anne A M W, Peelen Myrthe, Timmers Maaike, Boer Kees, Smit Bert J, Van Rijn Rick R
Department of Obstetrics and Gynaecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Pediatr Radiol. 2009 Mar;39(3):232-8. doi: 10.1007/s00247-008-1079-3. Epub 2008 Dec 20.
Cocaine exposure during pregnancy has been reported to have detrimental effects on the fetus.
To describe the findings on cranial ultrasonography (CUS) as part of a neonatal screening programme for exposed neonates.
The study was a semiprospective analysis of a 12-year cohort of neonates born to mothers who had used cocaine during their pregnancy and who had follow-up according to a strict clinical protocol.
In total, 154 neonates (78 boys, 76 girls) were included, of whom 29 (19%) were born preterm, and 125 (81%) were born full-term. Abnormalities on CUS were seen in 37 neonates (24%; 95% CI 18-31%). The abnormalities were classified as minor in 20 (13%; 95% CI 9-19%) and mildly abnormal in 17 (11%; 95% CI 7-17%). None of the infants showed severe abnormalities. The abnormalities were not associated with the duration or maximum amount of cocaine use during pregnancy.
None of the infants had severe abnormalities. Detected abnormalities were not correlated with the duration or maximum amount of cocaine use. Given these findings, we feel that routine cranial ultrasonography in this population is not warranted.
据报道，孕期接触可卡因对胎儿有不利影响。
描述作为暴露新生儿新生儿筛查项目一部分的头颅超声检查（CUS）结果。
本研究是对一组为期12年的队列进行的半前瞻性分析，该队列中的新生儿母亲在孕期使用过可卡因，并根据严格的临床方案进行随访。
共纳入154例新生儿（78例男孩，76例女孩），其中29例（19%）早产，125例（81%）足月出生。37例新生儿（24%；95%可信区间18%-31%）CUS检查有异常。其中20例（13%；95%可信区间9%-19%）异常被分类为轻度，17例（11%；95%可信区间7%-17%）为轻度异常。无婴儿表现出严重异常。这些异常与孕期可卡因使用的持续时间或最大剂量无关。
无婴儿有严重异常。检测到的异常与可卡因使用的持续时间或最大剂量无关。基于这些发现，我们认为该人群中无需进行常规头颅超声检查。
