Callender J E, Grantham-McGregor S M, Walker S P, Cooper E S
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston, Jamaica.
Acta Paediatr. 1994 Nov;83(11):1182-7. doi: 10.1111/j.1651-2227.1994.tb18278.x.
Heavy infection with the geohelminth Trichuris trichiura causes the Trichuris dysentery syndrome (TDS). Growth retardation and anaemia are characteristic of TDS and both are associated with poor development. We have examined the growth and developmental responses to treatment in 19 children aged 27-84 months with TDS. Developmental levels (DQ) were measured with the Griffiths mental development scales. Compared with a control group matched for age, gender and neighbourhood, the TDS children initially had serious deficits in DQ (24 points, p < 0.001). After a year of anthelmintic treatment, the TDS children showed improvement in locomotor development (p < 0.001) compared with the controls. The TDS children also had initial deficits in height-for-age, weight-for-height, mid-upper arm circumference and haemoglobin levels. They caught up rapidly in indices of wasting (weight-for-height and mid-upper arm circumference) and showed steady improvement in height-for-age and haemoglobin levels. Catch-up in height was comparable to that of children recovering from coeliac disease. The importance of continuing prevention after initial treatment is highlighted.
土源性蠕虫鞭虫的重度感染会引发鞭虫痢疾综合征（TDS）。生长发育迟缓与贫血是TDS的特征，且二者均与发育不良有关。我们对19名年龄在27至84个月的患有TDS的儿童的生长发育对治疗的反应进行了研究。使用格里菲斯心理发展量表来测量发育水平（DQ）。与年龄、性别和社区相匹配的对照组相比，TDS儿童最初在DQ方面存在严重缺陷（24分，p<0.001）。经过一年的驱虫治疗，与对照组相比，TDS儿童在运动发育方面有改善（p<0.001）。TDS儿童在年龄别身高、身高别体重、上臂中部周长和血红蛋白水平方面最初也存在缺陷。他们在消瘦指标（身高别体重和上臂中部周长）方面迅速追赶，并且在年龄别身高和血红蛋白水平方面呈现出稳步改善。身高的追赶情况与乳糜泻康复儿童相当。这突出了初始治疗后持续预防的重要性。
