Weinblatt M E, Scimeca P, James-Herry A, Sahdev I, Kochen J
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
J Pediatr. 1995 Feb;126(2):263-5. doi: 10.1016/s0022-3476(95)70557-0.
A cytogenetically normal infant with Kostmann syndrome (severe congenital granulocytopenia) was treated with granulocyte colony-stimulating factor, which resulted in a rapid improvement in his neutrophil count and a resolution of recurrent infections. After 11 months of therapy, splenomegaly developed, with thrombocytopenia, anemia, circulating nucleated erythrocytes, and acquired monosomy 7, which evolved during a period of 7 months into acute nonlymphoblastic leukemia. The use of granulocyte colony-stimulating factor in patients with congenital marrow failure disorders may induce or hasten the onset of a malignant transformation.
一名患有科茨曼综合征（严重先天性粒细胞减少症）且细胞遗传学正常的婴儿接受了粒细胞集落刺激因子治疗，其中性粒细胞计数迅速改善，反复感染得到缓解。治疗11个月后，出现脾肿大，并伴有血小板减少、贫血、循环有核红细胞以及获得性7号染色体单体，在7个月的时间里演变为急性非淋巴细胞白血病。在先天性骨髓衰竭疾病患者中使用粒细胞集落刺激因子可能会诱导或加速恶性转化的发生。
