Lai C C, Andrus P K, Chiu T H
Department of Pharmacology, Medical College of Ohio, Toledo 43699-0008.
Neurosci Lett. 1994 Sep 26;179(1-2):37-40. doi: 10.1016/0304-3940(94)90929-6.
Hydroxyl radical production in the cerebral cortex, striatum and hippocampus of young (6 months), middle-aged (15 months) and old (28 months) Fisher 344 x Brown-Norway F1 rats was quantitated by measuring the salicylate hydroxyl radical-trapping product, 2,5-dihydroxybenzoic acid. The levels of hydroxyl radical between different age groups in each region examined were not statistically different. In all regions, with the exception of hippocampus from old rats which had a lower content of hydroxyl radical, the levels of hydroxyl radical were higher for middle-aged and old rats than young ones. There was no regional difference in the production of hydroxyl radicals, except that the level was significantly higher in striatum than in cortex for 15-month-old rats. The cerebral cortical nitric oxide synthase activities were similar in the three age groups studied.
通过测量水杨酸羟基自由基捕获产物2,5 - 二羟基苯甲酸，对年轻（6个月）、中年（15个月）和老年（28个月）的Fisher 344×Brown - Norway F1大鼠大脑皮质、纹状体和海马体中的羟基自由基生成量进行了定量分析。在所检查的每个区域中，不同年龄组之间的羟基自由基水平无统计学差异。在所有区域中，除了老年大鼠海马体中的羟基自由基含量较低外，中年和老年大鼠的羟基自由基水平高于年轻大鼠。羟基自由基的生成没有区域差异，只是15个月大的大鼠纹状体中的水平显著高于皮质。在所研究的三个年龄组中，大脑皮质一氧化氮合酶活性相似。
