Cucchi A
Divisione di Urologia, Policlinico S. Matteo, Pavia, Italy.
J Urol. 1995 Mar;153(3 Pt 1):681-4. doi: 10.1097/00005392-199503000-00037.
There were 40 patients with benign prostatic hypertrophy (mean age 66 +/- 9 years) who had an obstructed stable bladder on a pressure-flow study. After a mean of 18 months (range 5 to 64) urodynamic studies were repeated and 20 men (group 1, mean age 60 +/- 7 years) had a stable bladder, while 20 (group 2) who were older (mean age 71 +/- 7 years) had detrusor instability. In the latter 20 patients greater outflow obstruction was noted at the second assessment. What seems most interesting is that at time 1 group 2 patients had a significantly higher rate of increase in opening pressure, which would possibly characterize an early stage in the development of structural changes leading to detrusor instability. This finding might prove a reliable clue to predict the latter condition in men with a proximally obstructed stable bladder.
40例良性前列腺增生患者（平均年龄66±9岁）在压力-流率研究中存在膀胱出口梗阻且膀胱稳定。平均18个月（5至64个月）后重复进行尿动力学研究，20名男性（第1组，平均年龄60±7岁）膀胱稳定，而另外20名（第2组）年龄较大（平均年龄71±7岁）的患者存在逼尿肌不稳定。在后者这20例患者中，第二次评估时发现流出道梗阻更严重。最有意思的是，在第1阶段，第2组患者的开放压升高率显著更高，这可能是导致逼尿肌不稳定的结构变化发展早期阶段的特征。这一发现可能是预测膀胱出口近端梗阻且膀胱稳定男性患者发生逼尿肌不稳定的可靠线索。
