Langsdorf L J, Zydney A L
Department of Chemical Engineering, University of Delaware, Newark 19716.
Blood Purif. 1994;12(6):292-307. doi: 10.1159/000170178.
The effects of blood-membrane interactions on hydraulic permeability, sieving coefficients, and diffusive permeabilities of Cuprophan and AN69 polyacrylonitrile hemodialysis membranes were studied using polydisperse dextrans (MW 5,000-20,000). Blood contact had no effect on the transport characteristics of the Cuprophan, but it caused a significant reduction in all of the transport parameters for the AN69 membrane due to the formation of a layer of adsorbed plasma proteins on the upper surface of the membrane. The transport characteristics of the membrane after exposure to blood are described using a two-layer membrane model, with this model able to accurately account for the different effects of blood contact on the sieving coefficients and diffusive permeabilities as well as the observed asymmetry in solute transport through the blood-contacted membrane. These results have important implications for solute transport during clinical hemodialysis.
使用多分散葡聚糖（分子量5000 - 20000）研究了血膜相互作用对铜仿膜和AN69聚丙烯腈血液透析膜的水力渗透性、筛分系数和扩散渗透性的影响。血液接触对铜仿膜的传输特性没有影响，但由于在膜的上表面形成了一层吸附的血浆蛋白，导致AN69膜的所有传输参数都显著降低。使用双层膜模型描述了暴露于血液后的膜的传输特性，该模型能够准确解释血液接触对筛分系数和扩散渗透性的不同影响，以及溶质通过与血液接触的膜传输时观察到的不对称性。这些结果对临床血液透析过程中的溶质传输具有重要意义。
