Yu H, Diamandis E P, Zarghami N, Grass L
Department of Clinical Biochemistry, Toronto Western Division, Toronto Hospital, Ontario, Canada.
Breast Cancer Res Treat. 1994;32(3):291-300. doi: 10.1007/BF00666006.
We demonstrate that the steroid hormone receptor-positive breast carcinoma cell lines T-47D and MCF-7 can be induced by androgens, progestins, mineralocorticosteroids, glucocorticosteroids, and antiestrogens, to produce prostate specific antigen (PSA). Estrogens failed to induce such stimulation in both cell lines and, in addition, were able to block the induction by androgens in the cell line T-47D. These data support and extend our previous report on PSA production by breast tumors and describe an in vitro system which can be used to study the phenomenon for possible application in prognosis and design of new therapy.
我们证明，类固醇激素受体阳性的乳腺癌细胞系T-47D和MCF-7可被雄激素、孕激素、盐皮质激素、糖皮质激素和抗雌激素诱导产生前列腺特异性抗原（PSA）。雌激素未能在这两种细胞系中诱导这种刺激，此外，还能够阻断T-47D细胞系中雄激素的诱导作用。这些数据支持并扩展了我们之前关于乳腺肿瘤产生PSA的报告，并描述了一种体外系统，可用于研究这一现象，以便可能应用于预后评估和新疗法的设计。
