Niemir Z, Idasiak I, Ostrowski M, Polcyn M, Krzymański M
Pracowni Immunopatologii Chorób Nerek i Zgodności Tkanek Kliniki Nefrologii Instytutu Chorób Wewnetrznych, Akademii Medycznej, Poznaniu.
Przegl Lek. 1994;51(8):333-8.
The urinary excretion of alpha-1-micro-albumin (alpha 1m) and complement components (CCs) was evaluated in the urine of 49 patients suffering from chronic glomerulonephritis (GN). Nephrotic syndrome (NS) was shown in 18 cases and increased serum creatinine level (Pcr: 115.0-159.1 mumol/l) in 9 patients. The most frequent CCs presence and the highest values of alpha 1m excretion were found in patients with membranous GN. In the early phase of the disease the alpha 1m urinary excretion was higher in subjects with NS than in those not showing the feature of it, independently of the morphological basis of the disease. Also CCs were detected mainly in the nephrotic patients. As the glomerular filtration improved a significant decrease in the urinary alpha 1m excretion was observed. The application of steroid immunosuppressive therapy resulted in the decrease of alpha 1m as well as CCs excretion. The results seem to point out that the increased alpha 1m and CCs excretion may be secondary to the activity of glomerular alternations as well as to the disturbances in glomerular blood flow.
对49例慢性肾小球肾炎（GN）患者的尿液进行了α1-微白蛋白（α1m）和补体成分（CCs）的尿排泄评估。18例患者出现肾病综合征（NS），9例患者血清肌酐水平升高（Pcr：115.0 - 159.1μmol/l）。膜性GN患者中CCs出现频率最高，α1m排泄值最高。在疾病早期，NS患者的α1m尿排泄高于未表现出该特征的患者，与疾病的形态学基础无关。CCs也主要在肾病患者中检测到。随着肾小球滤过功能改善，观察到尿α1m排泄显著下降。应用类固醇免疫抑制治疗导致α1m以及CCs排泄减少。结果似乎表明，α1m和CCs排泄增加可能继发于肾小球病变的活动以及肾小球血流紊乱。
