Hu Q, Shi Y L
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai.
Sheng Li Xue Bao. 1994 Dec;46(6):575-80.
The effects of Paeonol (25 micrograms/ml to 400 micrograms/ml) on the membrane currents of NG108-15 cells were observed by means of whole cell voltage-clamp technique. The results showed that PA inhibited delayed outward K+ current (IK), and to a less extend, that the Na+ current (INa). Two Ca2+ currents (T and L type) were also inhibited significantly. All of the effects mentioned above were dose-dependent and reversible.
采用全细胞膜片钳技术观察丹皮酚（25微克/毫升至400微克/毫升）对NG108-15细胞膜电流的影响。结果表明，丹皮酚抑制延迟外向钾电流（IK），对钠电流（INa）的抑制作用较小。两种钙电流（T型和L型）也受到显著抑制。上述所有作用均呈剂量依赖性且可逆。
