Alfieri A B, Cubeddu L X
Department of Pharmacology, School of Pharmacy, Central University of Venezuela.
Br J Cancer. 1995 Mar;71(3):629-32. doi: 10.1038/bjc.1995.123.
To test the role of serotonin in chemotherapy-induced nausea and emesis, ten cancer patients were pretreated with the serotonin synthesis inhibitor para-chlorophenylalanine (PCPA). PCPA (2 g 8 hourly for 2 or 3 days prior to cisplatin) reduced the spontaneous urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), inhibited the increase in urinary 5-HIAA induced by cisplatin and markedly attenuated the acute period of nausea and vomiting associated with the cytotoxic drug. These results indicate that gastrointestinal serotonin mediates cisplatin-induced emesis and that the amount of serotonin released by cisplatin is a major factor in determining the severity of the acute period of emesis experienced by the patient.
为了测试血清素在化疗引起的恶心和呕吐中的作用，十名癌症患者用血清素合成抑制剂对氯苯丙氨酸（PCPA）进行了预处理。PCPA（在顺铂治疗前2或3天，每8小时2克）降低了5-羟吲哚乙酸（5-HIAA）的自发性尿排泄，抑制了顺铂诱导的尿5-HIAA增加，并显著减轻了与细胞毒性药物相关的恶心和呕吐急性期。这些结果表明，胃肠道血清素介导顺铂引起的呕吐，顺铂释放的血清素量是决定患者呕吐急性期严重程度的主要因素。
