• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Nonrandom loss of human chromosome 3 fragments from mouse-human microcell hybrids following progressive growth in SCID mice.

作者信息

Imreh S, Kholodnyuk I, Allikmetts R, Stanbridge E J, Zabarovsky E R, Klein G

机构信息

Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

出版信息

Genes Chromosomes Cancer. 1994 Dec;11(4):237-45. doi: 10.1002/gcc.2870110406.

DOI:10.1002/gcc.2870110406
PMID:7533527
Abstract

Microcell hybrid lines of A9 mouse fibrosarcoma containing complete or partially deleted human chromosomes 3 (chr. 3) were inoculated into SCID mice. Cell lines derived from the tumors were examined by fluorescent in situ hybridization for the status of the transferred human chromosome and by PCR for marker loss. The SCID tumors arising after the inoculation of 10(5) cells were passaged serially in vivo and regularly showed loss of four markers; D3S1029 (3p21.3-21.2), AP20R (3p22-21.3, D3S32 (3p21.3-p21.2), and THRB (3p24). This regularly deleted region is bordered by markers GNA12 (3p21.1-p21.3) and VHL (3p25) that were maintained in a fraction of tumors. Fragments derived from the long arm of chromosome 3 and corresponding markers in the 3q26-q28 region were retained in all tumors. Our findings may be related to the postulated presence of tumor suppressor genes in the 3p24-p21 region as indicated by the frequent deletion of this region in renal and small cell lung carcinomas and other solid tumors. The technically cumbersome identification of suppressor genes may be supplemented by an "elimination test" based on analogous principles.

摘要

相似文献

1
Nonrandom loss of human chromosome 3 fragments from mouse-human microcell hybrids following progressive growth in SCID mice.
Genes Chromosomes Cancer. 1994 Dec;11(4):237-45. doi: 10.1002/gcc.2870110406.
2
A 3p21.3 region is preferentially eliminated from human chromosome 3/mouse microcell hybrids during tumor growth in SCID mice.在SCID小鼠的肿瘤生长过程中，人染色体3/小鼠微细胞杂交体中的3p21.3区域优先被消除。
Genes Chromosomes Cancer. 1997 Mar;18(3):200-11.
3
Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM.
Genes Chromosomes Cancer. 1997 Dec;20(4):329-36.
4
Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice.在严重联合免疫缺陷（SCID）小鼠体内的肿瘤生长过程中，人类3号染色体的相似区域在人/人及人/小鼠微细胞杂种中被消除或保留。
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1136-41. doi: 10.1073/pnas.98.3.1136.
5
Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors.在单染色体人/小鼠微细胞杂交衍生的严重联合免疫缺陷小鼠肿瘤中，位于3p14.2的人类脆性组氨酸三联体基因失活。
Cancer Res. 2000 Dec 15;60(24):7119-25.
6
Differential elimination of 3p and retention of 3q segments in human/mouse microcell hybrids during tumor growth.
Genes Chromosomes Cancer. 1997 Nov;20(3):224-33.
7
The microcell hybrid-based "elimination test" identifies a 1-Mb putative tumor-suppressor region at 3p22.2-p22.1 centromeric to the homozygous deletion region detected in lung cancer.基于微细胞杂交的“消除试验”在肺癌中检测到的纯合缺失区域着丝粒方向的3p22.2 - p22.1处鉴定出一个1兆碱基的假定肿瘤抑制区域。
Genes Chromosomes Cancer. 2002 Jul;34(3):341-4. doi: 10.1002/gcc.10068.
8
A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors.一个跨越微细胞杂交衍生的重症联合免疫缺陷（SCID）肿瘤中常见消除区域1（CER1）的1兆碱基对的噬菌体人工染色体（PAC）重叠群。
Genomics. 1999 Dec 1;62(2):147-55. doi: 10.1006/geno.1999.5952.
9
Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC).探讨散发性肾透明细胞癌（cRCC）中除 VHL 以外的 3p 缺失肿瘤抑制基因。
Urol Oncol. 2013 Oct;31(7):1333-42. doi: 10.1016/j.urolonc.2011.08.012. Epub 2011 Oct 1.
10
Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice.
Cancer Lett. 2003 Mar 10;191(2):155-64. doi: 10.1016/s0304-3835(02)00677-8.

引用本文的文献

1
GWAS reveals genetic basis of a predisposition to severe COVID-19 through modeling of the FYCO1 protein.全基因组关联研究通过对FYCO1蛋白进行建模揭示了重症新型冠状病毒肺炎易感性的遗传基础。
Front Med (Lausanne). 2023 Jul 20;10:1178939. doi: 10.3389/fmed.2023.1178939. eCollection 2023.
2
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.位于染色体3p21.3区域编码的基因LIMD1，是一种参与人类肺癌发生发展的关键肿瘤抑制基因。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19932-7. doi: 10.1073/pnas.0805003105. Epub 2008 Dec 5.
3
Mandatory chromosomal segment balance in aneuploid tumor cells.
非整倍体肿瘤细胞中必需的染色体片段平衡。
BMC Cancer. 2007 Jan 26;7:21. doi: 10.1186/1471-2407-7-21.
4
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.含LIM结构域蛋白1（LIMD1）是一种由染色体3p21.3编码的肿瘤抑制因子，它与视网膜母细胞瘤蛋白（pRB）结合并抑制E2F驱动的转录。
Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16531-6. doi: 10.1073/pnas.0407123101. Epub 2004 Nov 12.
5
Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3.人类3号染色体上同线性断点与恶性肿瘤相关缺失的重合。
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6622-7. doi: 10.1073/pnas.0430971100. Epub 2003 May 8.
6
Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice.在严重联合免疫缺陷（SCID）小鼠体内的肿瘤生长过程中，人类3号染色体的相似区域在人/人及人/小鼠微细胞杂种中被消除或保留。
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1136-41. doi: 10.1073/pnas.98.3.1136.
7
Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3.一个定位于染色体3p21.3的鼻咽癌抑癌基因的功能证据。
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3042-7. doi: 10.1073/pnas.95.6.3042.
8
Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization.
Chromosome Res. 1996 Jun;4(4):310-3. doi: 10.1007/BF02263683.