一个定位于染色体3p21.3的鼻咽癌抑癌基因的功能证据。
Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3.
作者信息
Cheng Y, Poulos N E, Lung M L, Hampton G, Ou B, Lerman M I, Stanbridge E J
机构信息
University of California, Irvine, Irvine, CA 92697-4025, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3042-7. doi: 10.1073/pnas.95.6.3042.
Abstract
Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.
摘要
鼻咽癌是一种在东南亚人群中普遍存在的恶性肿瘤。流行病学研究表明，遗传易感性、爱泼斯坦-巴尔病毒和环境因素可能在决定发病率方面发挥作用。分子研究表明3号染色体短臂上存在一个抑癌基因。在本研究中，我们通过单染色体转移为3p21.3染色体上的抑癌基因活性提供了功能证据。
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