P物质对心脏的局部作用：乙酰胆碱和去甲肾上腺素的作用
Local cardiac effects of substance P: roles of acetylcholine and noradrenaline.
作者信息
Chiao H, Caldwell R W
机构信息
Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta 30912-2300.
出版信息
Br J Pharmacol. 1995 Jan;114(2):283-8. doi: 10.1111/j.1476-5381.1995.tb13224.x.
Abstract
- The local cardiac actions of substance P were examined in isolated perfused hearts and atria of the guinea-pig. 2. In both hearts and right atria, substance P caused negative inotropic and chronotropic effects. 3. Atropine (10(-6) M) or depletion of acetylcholine, by electrical stimulation and hemicholinium-3 perfusion, significantly attenuated the negative inotropic and chronotropic effects of substance P. alpha- and beta-adrenoceptor blockade by nadolol and phentolamine (10(-6) M each) did not prevent the negative inotropic and chronotropic effects of substance P. This indicates that cholinergic neurones, but not adrenergic neurones, partially mediate the effects of substance P. 4. There was no significant difference in the effects of substance P observed between groups with acetylcholine depletion and with cholinoceptor blockade. This suggests that substance P elicits its effects mainly through release of acetylcholine. 5. These results indicate that substance P has negative inotropic and chronotropic effects in guinea-pig hearts and right atria mediated partly by release of acetylcholine. Substance P also appears to have direct effects on cardiac tissue.
摘要
- 在豚鼠离体灌流心脏和心房中研究了P物质的局部心脏作用。2. 在心脏和右心房中，P物质均引起负性变力性和变时性效应。3. 阿托品（10⁻⁶ M）或通过电刺激和用3-羟甲基苯胺灌注耗竭乙酰胆碱，可显著减弱P物质的负性变力性和变时性效应。纳多洛尔和酚妥拉明（各10⁻⁶ M）对α和β肾上腺素能受体的阻断并不能阻止P物质的负性变力性和变时性效应。这表明胆碱能神经元而非肾上腺素能神经元部分介导了P物质的效应。4. 在乙酰胆碱耗竭组和胆碱能受体阻断组之间观察到的P物质效应无显著差异。这表明P物质主要通过释放乙酰胆碱发挥其效应。5. 这些结果表明，P物质在豚鼠心脏和右心房中具有负性变力性和变时性效应，部分由乙酰胆碱的释放介导。P物质似乎也对心脏组织有直接作用。
相似文献
1
Local cardiac effects of substance P: roles of acetylcholine and noradrenaline.P物质对心脏的局部作用：乙酰胆碱和去甲肾上腺素的作用
Br J Pharmacol. 1995 Jan;114(2):283-8. doi: 10.1111/j.1476-5381.1995.tb13224.x.
2
Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria.豚鼠心房交感神经和副交感神经的钙通道亚型
Br J Pharmacol. 1995 Sep;116(1):1577-82. doi: 10.1111/j.1476-5381.1995.tb16375.x.
3
Inhibition by omega-conotoxin GVIA of the chronotropic responses to sympathetic and parasympathetic nerve stimulation in the isolated, blood-perfused atrium of the dog.ω-芋螺毒素GVIA对犬离体血液灌注心房中交感和副交感神经刺激所致变时反应的抑制作用。
J Auton Pharmacol. 1993 Aug;13(4):257-65. doi: 10.1111/j.1474-8673.1993.tb00273.x.
4
Subtypes of muscarinic receptor on cholinergic nerves and atrial cells of chicken and guinea-pig hearts.鸡和豚鼠心脏胆碱能神经及心房细胞上毒蕈碱受体的亚型
Br J Pharmacol. 1988 Feb;93(2):357-66. doi: 10.1111/j.1476-5381.1988.tb11442.x.
5
Positive chronotropic and inotropic responses to lysophosphatidylcholine are mediated by norepinephrine released from myocardial sympathetic nerve terminals.溶血磷脂酰胆碱引起的正性变时和变力反应是由心肌交感神经末梢释放的去甲肾上腺素介导的。
Gen Pharmacol. 1993 Jan;24(1):239-41. doi: 10.1016/0306-3623(93)90041-u.
6
Effects of volatile anesthetics on response to norepinephrine and acetylcholine in guinea pig atria.挥发性麻醉剂对豚鼠心房去甲肾上腺素和乙酰胆碱反应的影响。
Anesth Analg. 1991 Sep;73(3):304-9. doi: 10.1213/00000539-199109000-00014.
7
Effect of ondansetron on the contractile responses to positive inotropic agents in electrically driven left atria of rats.昂丹司琼对大鼠电驱动左心房中强心剂收缩反应的影响。
J Basic Clin Physiol Pharmacol. 2001;12(4):271-87. doi: 10.1515/jbcpp.2001.12.4.271.
8
Positive chronotropic and inotropic responses to release of norepinephrine from sympathetic nerve terminals produced by nitroglycerin in atria.硝酸甘油使交感神经末梢释放去甲肾上腺素，从而引起心房出现正性变时和变力反应。
Arch Int Pharmacodyn Ther. 1991 Jan-Feb;309:125-36.
9
Cholinergic neurons are involved in the effect of substance P on the circular muscle of the guinea pig small intestine.胆碱能神经元参与了P物质对豚鼠小肠环行肌的作用。
Acta Physiol Hung. 1992;80(1-4):311-6.
10
Characterization of responses to neurokinin A in the isolated perfused guinea pig heart.离体灌注豚鼠心脏对神经激肽A反应的特征分析
Am J Physiol. 1998 Dec;275(6):R1803-11. doi: 10.1152/ajpregu.1998.275.6.R1803.
引用本文的文献
1
Substance P Receptor in the Rat Heart and Regulation of Its Expression in Long-Term Diabetes.大鼠心脏中的P物质受体及其在长期糖尿病中的表达调控
Front Physiol. 2018 Jul 13;9:918. doi: 10.3389/fphys.2018.00918. eCollection 2018.
2
Cardiovascular biology of the incretin system.肠促胰岛素系统的心血管生物学。
Endocr Rev. 2012 Apr;33(2):187-215. doi: 10.1210/er.2011-1052. Epub 2012 Feb 8.
3
Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin.复苏大鼠中海卡辛的心血管作用易感性增加。二氢海卡辛的心血管作用。
BMC Cardiovasc Disord. 2010 Aug 31;10:39. doi: 10.1186/1471-2261-10-39.
4
Role of substance P in viral myocarditis in mice.P物质在小鼠病毒性心肌炎中的作用。
Heart Vessels. 2010 Jul;25(4):348-52. doi: 10.1007/s00380-009-1189-3. Epub 2010 Jul 31.
5
The role of substance P in myocardial dysfunction during ischemia and reperfusion.P物质在缺血再灌注期间心肌功能障碍中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Mar;353(4):400-7. doi: 10.1007/BF00261436.
6
The ineffectiveness of the NO-cyclic GMP signaling pathway in the atrial myocardium.一氧化氮-环磷酸鸟苷信号通路在心房心肌中的无效性。
Br J Pharmacol. 1995 Dec;116(7):3061-7. doi: 10.1111/j.1476-5381.1995.tb15964.x.
本文引用的文献
1
Nitric oxide attenuates cardiac myocyte contraction.一氧化氮可减弱心肌细胞的收缩。
Am J Physiol. 1993 Jul;265(1 Pt 2):H176-82. doi: 10.1152/ajpheart.1993.265.1.H176.
2
Substance P increases cyclic GMP levels on coronary postcapillary venular endothelial cells.P物质可提高冠状毛细血管后微静脉内皮细胞内环磷酸鸟苷水平。
Life Sci. 1993;53(14):PL229-34. doi: 10.1016/0024-3205(93)90556-i.
3
Functional difference between SP and NKA: relaxation of gastric muscle by SP is mediated by VIP and NO.速激肽（SP）和神经激肽A（NKA）之间的功能差异：速激肽对胃肌的舒张作用是由血管活性肠肽（VIP）和一氧化氮（NO）介导的。
Am J Physiol. 1993 Apr;264(4 Pt 1):G678-85. doi: 10.1152/ajpgi.1993.264.4.G678.
4
Purification and characterisation of a membrane-bound substance-P-degrading enzyme from human brain.人脑海膜结合物质P降解酶的纯化与特性分析
Eur J Biochem. 1981 Feb;114(2):315-27. doi: 10.1111/j.1432-1033.1981.tb05151.x.
5
beta-Adrenoceptor ligand binding and supersensitivity to isoprenaline of ventricular muscle after chronic reserpine pretreatment.慢性利血平预处理后心室肌β-肾上腺素能受体配体结合及对异丙肾上腺素的超敏感性
Naunyn Schmiedebergs Arch Pharmacol. 1982 Sep;320(3):240-5. doi: 10.1007/BF00510135.
6
Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin- and substance P-like immunoreactive nerves.血管活性肠肽样免疫反应性物质在哺乳动物心脏中的分布。与神经降压素样和P物质样免疫反应性神经的相互关系。
Cell Tissue Res. 1984;236(3):527-40. doi: 10.1007/BF00217219.
7
Capsaicin-induced stimulation of the guinea-pig atrium. Involvement of a novel sensory transmitter or a direct action on myocytes?辣椒素对豚鼠心房的刺激作用。是涉及一种新型感觉递质还是对心肌细胞的直接作用？
Naunyn Schmiedebergs Arch Pharmacol. 1984 Feb;325(2):176-82. doi: 10.1007/BF00506198.
8
Detection of substance P-like immunoreactivity in nerve fibers in the heart of guinea-pigs but not rats.在豚鼠而非大鼠的心脏神经纤维中检测到P物质样免疫反应性。
J Auton Nerv Syst. 1983 Jul;8(3):295-301. doi: 10.1016/0165-1838(83)90113-3.
9
Direct evidence for a release of acetylcholine from the myenteric plexus of guinea pig small intestine by substance P.P物质促使豚鼠小肠肌间神经丛释放乙酰胆碱的直接证据。
Eur J Pharmacol. 1982 Jul 30;81(4):665-8. doi: 10.1016/0014-2999(82)90357-0.
10
Depletion by capsaicin of substance P-immunoreactivity and acetylcholinesterase activity from nerve fibres in the guinea-pig heart.辣椒素对豚鼠心脏神经纤维中P物质免疫反应性和乙酰胆碱酯酶活性的耗竭作用。
Neurosci Lett. 1981 Nov 18;27(1):47-53. doi: 10.1016/0304-3940(81)90204-4.
Zotero 插件