溶血磷脂酰胆碱引起的正性变时和变力反应是由心肌交感神经末梢释放的去甲肾上腺素介导的。

Positive chronotropic and inotropic responses to lysophosphatidylcholine are mediated by norepinephrine released from myocardial sympathetic nerve terminals.

Tanaka H, Ikeda U, Shigenobu K

Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

Gen Pharmacol. 1993 Jan;24(1):239-41. doi: 10.1016/0306-3623(93)90041-u.

Abstract

The effects of beta-adrenoceptor blockade and reserpinization on the positive chronotropic and inotropic responses to lysophosphatidylcholine (LPC) were examined in isolated atrial and ventricular preparations from rat hearts. 2. The positive responses to 10(-4) M LPC were about 40-55% of those to 10(-5) M norepinephrine (NE) in each preparation. 3. The responses to LPC in the presence of propranolol or in the reserpinized preparations were significantly smaller than the corresponding values obtained in control preparations, and were about 10-25% of those to NE. 4. It was concluded that positive chronotropic and inotropic responses to LPC are at least partially mediated by release of NE from myocardial sympathetic nerve terminals.

摘要

在大鼠心脏的离体心房和心室标本中，研究了β-肾上腺素能受体阻断和利血平化对溶血磷脂酰胆碱（LPC）引起的正性变时性和变力性反应的影响。2. 在每个标本中，对10(-4) M LPC的正性反应约为对10(-5) M去甲肾上腺素（NE）的正性反应的40 - 55%。3. 在普萘洛尔存在下或利血平化的标本中，对LPC的反应明显小于对照标本中的相应值，约为对NE反应的10 - 25%。4. 得出的结论是，对LPC的正性变时性和变力性反应至少部分是由心肌交感神经末梢释放NE介导的。