Moreno M J, Pellicer S, Marti A, Arenas J C, Fernández-Otero M P
Department of Physiology and Nutrition, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Oct;109(2):159-66.
Lindane (gamma-hexachlorocyclohexane) influence on the in vitro intestinal transport of D-galactose and L-leucine has been studied in isolated chicken enterocytes. Animals were injected i.p. with 30 mg/kg b.w. of the pesticide over 7 days. Total uptake of D-galactose and L-leucine was significantly decreased by lindane action. There was no alteration in the non-mediated component, but the mediated transport was markedly inhibited in both cases. Furthermore, the exit of D-galactose across the basolateral membrane, as well as (Na(+)-K+)-ATPase activity, was significantly decreased in pesticide-treated chickens.
已在分离的鸡肠上皮细胞中研究了林丹（γ-六氯环己烷）对D-半乳糖和L-亮氨酸体外肠道转运的影响。给动物腹腔注射30毫克/千克体重的该农药，持续7天。林丹的作用使D-半乳糖和L-亮氨酸的总摄取量显著降低。非介导成分没有改变，但在这两种情况下介导转运均受到明显抑制。此外，在经农药处理的鸡中，D-半乳糖跨基底外侧膜的流出以及（Na⁺-K⁺）-ATP酶活性均显著降低。
