Zaviacic M, Ruzicková M, Jakubovský J, Danihel L, Babál P, Blazeková J
Ustav patologickej anatómie LFUK, Bratislava, Slovakia.
Bratisl Lek Listy. 1994 Nov;95(11):491-7.
In addition to knowledge gained in the first half of the 8th decade, the evidence of cross-antigenicity between male prostate and Skene's glands by means of PSA and PSAcP demonstrations in Skene's glands and ducts justifies utilization of the term prostate in both sexes. The authors compared the results of immunohistochemical examination of prostatic markers by means of the PAP method which was used at the beginning of the 8th decade, with that of BSAP technique. Prostatic tissues of 11 females and children at the age ranging from 5 to 71 years were examined. The results gained by means of the BSAP method were identical with those gained by means of the PAP method. Prostatic markers PSA and PSAcP were expressed on the surface and in apical cytoplasm of cells lining the prostatic ducts, and in prostatic glands. The authors proved the expression also in membranes of the stratified cylindrical epithelial cells of the ducts, and in female prostatic fluid in ducts and glands, especially PSAcP. Even though both immunohistochemical methods brought identical results, the authors recommend to prefer the BSAP method to the PAP method due to optically more contrast expression. (Fig. 8, Ref. 36.)
除了在80年代上半叶获得的知识外，通过在斯基恩氏腺和导管中进行前列腺特异性抗原（PSA）和前列腺酸性磷酸酶（PSAcP）检测，证明男性前列腺与斯基恩氏腺之间存在交叉抗原性，这使得“前列腺”一词在两性中都适用。作者将80年代初使用的过氧化物酶抗过氧化物酶（PAP）法免疫组化检测前列腺标志物的结果与碱性磷酸酶抗碱性磷酸酶（BSAP）技术的结果进行了比较。对11名年龄在5至71岁之间的女性和儿童的前列腺组织进行了检查。通过BSAP法获得的结果与通过PAP法获得的结果相同。前列腺标志物PSA和PSAcP在前列腺导管内衬细胞的表面和顶端细胞质中以及前列腺腺体内均有表达。作者还证明在导管的复层柱状上皮细胞膜以及导管和腺体内的女性前列腺液中也有表达，尤其是PSAcP。尽管两种免疫组化方法得出的结果相同，但由于光学上对比度更高的表达，作者建议优先选择BSAP法而非PAP法。（图8，参考文献36）
