Conditioning effects of sural nerve stimulation on short and long latency motor evoked potentials in lower limb muscles.

The effects of conditioning sural nerve stimulation on motor evoked potentials (MEPs) in relaxed muscles of the lower limb were examined in 11 healthy adults. The study tested the hypothesis that cutaneous afferent stimulation, in the absence of muscle afferent input, facilitates the short latency MEPs evoked in lower limb muscles following transcranial magnetic stimulation of motor cortex. Non-painful (3.6 x sensory threshold) percutaneous electrical stimulation was delivered to the sural nerve at conditioning (C)-test (T) intervals of 0-150 msec. MEPs were elicited bilaterally in the tibialis anterior (TA) and lateral gastrocnemius (LG) muscles with and without preceding cutaneous stimulation. Mean MEP amplitudes were facilitated in the ipsilateral TA by 258% (n = 10 of 11), the ipsilateral LG by 275% (n = 7 of 8) and the contralateral TA by 313% (n = 7 of 7) within C-T: 60-100 msec. These results establish that cutaneous afferent stimulation per se does lead to a facilitation of short latency MEPs. In addition, two subjects who were examined at higher stimulation intensities both exhibited late responses (70-95 msec) at C-T: 0-15 msec. These responses, which were independent of the amplitude and appearance of short latency MEPs, suggest a convergence of the cutaneous stimulation with late arriving descending cortical or cortico-bulbospinal inputs to the target motoneuron pool.(ABSTRACT TRUNCATED AT 250 WORDS)