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免疫无知的自身反应性T细胞、表位扩展与受体库限制

Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation.

作者信息

Elson C J, Barker R N, Thompson S J, Williams N A

机构信息

University of Bristol Dept of Pathology and Microbiology, UK.

出版信息

Immunol Today. 1995 Feb;16(2):71-6. doi: 10.1016/0167-5699(95)80091-3.

DOI:10.1016/0167-5699(95)80091-3
PMID:7534085
Abstract

The factors that may cause antigen-presenting cells to alter the pattern of protein processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.

摘要

可能导致抗原呈递细胞改变蛋白质加工方式并将其呈递给自身反应性T细胞，从而引发自身免疫性疾病的因素，目前仍存在争议。在本文中，克里斯·埃尔森及其同事提出，与辅助性T细胞1（Th1）相关的细胞因子会改变蛋白质的加工过程，而这种效应可被与Th2相关的细胞因子抵消。

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