Berger R, Derré J, Le Coniat M, Hébert J, Romana P S, Jonveaux P
Unité INSERM U 301, Montreal, Canada.
Genes Chromosomes Cancer. 1995 Jan;12(1):58-62. doi: 10.1002/gcc.2870120110.
Cytogenetic studies of three acute myelomonocytic leukemias with bone marrow eosinophilia (M4EO) revealed chromosome 16 inversion associated with additional abnormalities. The inverted chromosome 16 was involved in two patients. Fluorescence in situ hybridization (FISH) experiments with a YAC probe detecting inv(16) showed that the translocation breakpoints involving chromosome 16 did not implicate the inversion breakpoints. FISH can thus distinguish between true variant translocations and translocations with other breakpoints on chromosome 16 in M4EO.
对三例伴有骨髓嗜酸性粒细胞增多的急性粒单核细胞白血病（M4EO）进行的细胞遗传学研究显示，16号染色体倒位并伴有其他异常。两名患者出现了倒位的16号染色体。使用检测inv(16)的YAC探针进行的荧光原位杂交（FISH）实验表明，涉及16号染色体的易位断点与倒位断点无关。因此，FISH可以区分M4EO中真正的变异易位和16号染色体上具有其他断点的易位。
