胶质瘤中MET基因的扩增
Amplification of the MET gene in glioma.
作者信息
Fischer U, Müller H W, Sattler H P, Feiden K, Zang K D, Meese E
机构信息
Department of Human Genetics, University of Saar, Homburg, Germany.
出版信息
Genes Chromosomes Cancer. 1995 Jan;12(1):63-5. doi: 10.1002/gcc.2870120111.
We have previously reported the finding of MET amplification linked to double minutes (dmins) in a human glioblastoma (TX3095). Because dmins are found in approximately 50% of glioblastomas, 18 gliomas were analyzed for MET amplification. Three grade IV glioblastomas and one grade II astrocytoma showed amplification. We could also localize the MET amplicon to dmins in glioblastoma TX3095 by fluorescence in situ hybridization.
我们之前曾报道在一例人类胶质母细胞瘤（TX3095）中发现与双微体（dmins）相关的MET扩增。由于约50%的胶质母细胞瘤中存在双微体，因此对18例胶质瘤进行了MET扩增分析。3例IV级胶质母细胞瘤和1例II级星形细胞瘤显示出扩增。我们还通过荧光原位杂交将胶质母细胞瘤TX3095中的MET扩增子定位到双微体上。
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