参与致癌作用和进化的染色体外癌基因的生物发生及作用。
The biogenesis and roles of extrachromosomal oncogene involved in carcinogenesis and evolution.
作者信息
Wei Jianxia, Wu Chunchun, Meng Hanbing, Li Mengna, Niu Weihong, Zhan Yuting, Jin Long, Duan Yumei, Zeng Zhaoyang, Xiong Wei, Li Guiyuan, Zhou Ming
机构信息
NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha 410013, Hunan, China.
Cancer Research Institute and School of Basic Medical Sciences, Central South University Changsha 410078, Hunan, China.
出版信息
Am J Cancer Res. 2020 Nov 1;10(11):3532-3550. eCollection 2020.
Abstract
More and more extrachromosomal DNA (ecDNA) was found in human tumor cells in recent years, which has a high copy number in tumors and changes the expression of oncogenes, thus different from normal chromosomal DNA. These circular structures were identified to originate from chromosomes, and play critical roles in rapid carcinogenesis, tumor evolution and multidrug resistance. Therefore, this review mostly focuses on the biogenesis and regulation of extrachromosomal oncogene in ecDNA as well as its function and mechanism in tumors, which are of great significance for our comprehensive understanding of the role of ecDNA in tumor carcinogenic mechanism and are expected to provide ecDNA with the potential to be a new molecular target for the diagnosis and treatment of tumors.
摘要
近年来，在人类肿瘤细胞中发现了越来越多的染色体外DNA（ecDNA），其在肿瘤中具有高拷贝数并改变癌基因的表达，因此不同于正常染色体DNA。这些环状结构被鉴定为起源于染色体，并在快速致癌、肿瘤进化和多药耐药中发挥关键作用。因此，本综述主要关注ecDNA中染色体外癌基因的生物发生和调控及其在肿瘤中的功能和机制，这对于我们全面了解ecDNA在肿瘤致癌机制中的作用具有重要意义，有望为ecDNA成为肿瘤诊断和治疗的新分子靶点提供潜力。
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