Siracusano S, Mandras R, Belgrano E
Istituto di Clinica Urologica, Università degli Studi, Sassari.
Arch Ital Urol Androl. 1994 Sep;66(4 Suppl):155-7.
It's known that benign prostatic hypertrophy arise from the glands that surround the proximal prostatic urethra. In these cases voiding disorders may be due by detrusor instability alone or associated with cervical urethral obstruction. At first Griffiths and Schafer and subsequently Sarky have introduced some correlations that are able to differentiate the bladder outlet obstruction from the impaired detrusor contractility. On the contrary with regard to the behaviour of detrusor during obstruction, in connection with histological findings, several interpretations have been expressed. The theory more credited has been expressed by Gosling who has showed a reduction of the parasympathetic innervation of detrusor and consequent hypersensitivity due to denervation.
众所周知，良性前列腺增生起源于前列腺近端尿道周围的腺体。在这些情况下，排尿障碍可能仅由逼尿肌不稳定引起，或与尿道颈梗阻相关。起初，格里菲斯和谢弗，随后萨基引入了一些能够区分膀胱出口梗阻与逼尿肌收缩功能受损的相关性。相反，关于梗阻期间逼尿肌的行为，结合组织学发现，已经有了几种解释。最受认可的理论是由戈斯林提出的，他表明逼尿肌的副交感神经支配减少，以及由于去神经支配导致的超敏反应。
