人类免疫缺陷病毒1型围产期感染儿童的高水平免疫球蛋白A。抗原特异性及P物质血浆水平升高的可能作用。

High levels of IgA in HIV-1-perinatally-infected children. Antigen specificity and possible role of increased substance P plasma levels.

作者信息

Rossi M E, Resti M, Azzari C, Calabri G, De Martino M, Galli L, Carbonella R, Vierucci A

机构信息

Department of Pediatrics, University of Florence, Italy.

出版信息

Pediatr Allergy Immunol. 1994 Nov;5(4):240-3. doi: 10.1111/j.1399-3038.1994.tb00247.x.

DOI:10.1111/j.1399-3038.1994.tb00247.x

PMID:7534587

Abstract

The specificity of IgA against food, inhalant, bacterial and fungine antigens as well as for HIV-1 proteins was investigated in 14 HIV-1-infected children (CDC stage P-2) and 15 controls. IgA against food- and inhalant antigens as well as against tetanus toxoid were significantly more often present in the HIV positive children than in controls. No difference between the two groups was present for IgA against Candida albicans. A significant increase of substance P, a strong IgA synthesis inducing neuropeptide, was demonstrated in the plasma of HIV-1 infected children. In conclusion, high levels of IgA seem to reflect a complex immune dysfunction in which many factors are involved. The importance of neuroimmune dysregulation is discussed.

摘要

在14名感染HIV-1的儿童（疾病控制中心P-2期）和15名对照者中，研究了IgA针对食物、吸入性、细菌和真菌抗原以及HIV-1蛋白的特异性。与对照者相比，HIV阳性儿童中针对食物和吸入性抗原以及破伤风类毒素的IgA明显更常见。两组之间针对白色念珠菌的IgA没有差异。在感染HIV-1的儿童血浆中，强诱导IgA合成的神经肽P物质显著增加。总之，高水平的IgA似乎反映了一种涉及多种因素的复杂免疫功能障碍。讨论了神经免疫失调的重要性。