Nehéz M, Tóth C, Dési I
Department of Public Health, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Ecotoxicol Environ Saf. 1994 Dec;29(3):365-71. doi: 10.1016/0147-6513(94)90009-4.
The three organophosphorous insecticides dimethoate, dichlorvos, and parathion-methyl were investigated in subchronic experiments on bone marrow cell chromosomes. In the literature these compounds were reported to exhibit both positive and negative results in mutagenicity tests demanding further investigations in subchronic tests. The treatment of different groups of male Wistar rats lasted for 6 weeks with 5 treatment days per week at doses of 1/100, 1/75, and 1/50 of the LD50. Following the last treatment, bone marrow cell chromosomes were prepared. The frequency of cells revealing any aberrations as well as numeric and structural aberrations were evaluated. In this test both dimethoate and dichlorvos demonstrated mutagenic effects following subchronic treatment of Wistar rats, while parathion-methyl at doses of 1/100, 1/75, and 1/50 of LD50 displayed no significant mutagenicity.
在对骨髓细胞染色体进行的亚慢性实验中，研究了三种有机磷杀虫剂乐果、敌敌畏和甲基对硫磷。文献报道这些化合物在致突变性试验中呈现出阳性和阴性结果，因此需要在亚慢性试验中进一步研究。不同组雄性Wistar大鼠的处理持续6周，每周处理5天，剂量为半数致死量（LD50）的1/100、1/75和1/50。最后一次处理后，制备骨髓细胞染色体。评估出现任何畸变以及数值和结构畸变的细胞频率。在该试验中，乐果和敌敌畏在对Wistar大鼠进行亚慢性处理后均表现出致突变作用，而甲基对硫磷在LD50的1/100、1/75和1/50剂量下未显示出显著的致突变性。
