某些有机磷农药的遗传毒性作用。I. 对大鼠骨髓细胞微核的诱导作用
Genotoxic effects of some organophosphorous pesticides. I. Induction of micronuclei in bone marrow cells in rat.
作者信息
Grover I S, Malhi P K
出版信息
Mutat Res. 1985 Mar;155(3):131-4. doi: 10.1016/0165-1218(85)90131-4.
PMID:4038779
Abstract
The genotoxic effects of 4 organophosphorous pesticides, i.e. ekatin, fenitrothion, methylparathion and phorate, were examined employing the micronucleus test in bone marrow cells of the rat. Methylparathion and phorate were found to be mutagenic, while ekatin was weakly mutagenic. The frequency of micronuclei induction by fenitrothion did not differ significantly from that noticed in negative control.
摘要
采用大鼠骨髓细胞微核试验检测了4种有机磷农药（即克杀螨、杀螟硫磷、甲基对硫磷和甲拌磷）的遗传毒性。结果发现甲基对硫磷和甲拌磷具有致突变性，而克杀螨具有弱致突变性。杀螟硫磷诱导微核的频率与阴性对照组相比无显著差异。
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