人类前列腺肥大的多向性收缩

Multidirectional contraction of human hypertrophied prostate.

Moriyama N, Miyata N, Yamaura H, Yamazaki R, Tsuchida K, Kurimoto S, Nagase Y, Ishida Y, Kawabe K

Department of Urology, Faculty of Medicine, University of Tokyo, Japan.

Gen Pharmacol. 1994 Nov;25(7):1459-64. doi: 10.1016/0306-3623(94)90174-0.

Abstract

The purpose of the present investigation is to evaluate muscle contraction in two directions (longitudinal and circumferential to urethra) physiologically and morphologically for alpha-adrenoceptor agonists. 2. Norepinephrine (10(-7)-10(-4) M), phenylephrine (10(-7)-10(-4) M) and clonidine (10(-7)-10(-4) M) induced contractions in a dose-dependent manner on human prostate from patients with benign prostatic hypertrophy (BPH). 3. No significant differences were observed between longitudinal and circumferential directions of human prostate in 50% of the maximal muscle contraction (EC50 values) and the maximal muscle contractions caused by any agents used. 4. Morphometric analysis for muscle in prostates was performed using formalin-fixed, paraffin-embedded sections stained by the Mallory-Azan method. 5. There was no significant difference in the density of the muscle area between longitudinal and circumferential directions of prostatic strips. 6. These results suggest that there are no significant differences in responsiveness of alpha-adrenoceptor agonists and the smooth muscle contents in longitudinal and circumferential directions to urethra, for human hypertrophied prostate.

摘要

本研究的目的是从生理学和形态学角度评估α-肾上腺素能受体激动剂在两个方向（纵向和尿道圆周方向）上的肌肉收缩情况。2. 去甲肾上腺素（10⁻⁷ - 10⁻⁴ M）、去氧肾上腺素（10⁻⁷ - 10⁻⁴ M）和可乐定（10⁻⁷ - 10⁻⁴ M）对良性前列腺增生（BPH）患者的人前列腺组织呈剂量依赖性地诱导收缩。3. 在最大肌肉收缩的50%（EC50值）以及所使用的任何药物引起的最大肌肉收缩方面，未观察到人类前列腺纵向和圆周方向之间存在显著差异。4. 使用经福尔马林固定、石蜡包埋、经马洛里 - 阿赞法染色的切片对前列腺中的肌肉进行形态计量分析。5. 前列腺条带纵向和圆周方向之间的肌肉面积密度没有显著差异。6. 这些结果表明，对于人类增生性前列腺，α-肾上腺素能受体激动剂的反应性以及纵向和尿道圆周方向的平滑肌含量不存在显著差异。