α1肾上腺素受体阻滞剂布那唑嗪对人前列腺增生组织多向收缩反应及布那唑嗪结合位点定位的影响

Effect of bunazosin, alpha 1-adrenoceptor blocker, on multidirectional contractile response and localization of bunazosin binding sites in human hypertrophied prostate.

Moriyama N, Orikasa E, Nakamura T, Kurimoto S, Ishida Y, Kawabe K

Department of Urology, Faculty of Medicine, University of Tokyo, Japan.

Gen Pharmacol. 1995 Sep;26(5):1033-7. doi: 10.1016/0306-3623(94)00277-t.

Abstract

Effects of bunazosin, an alpha 1-adrenoceptor blocker, on the contraction induced by norepinephrine in human hypertrophied prostate were examined in vitro. 2. Prostatic specimens showed maximum contraction at 10(-4) M norepinephrine in longitudinal and circumferential directions to the urethra. 3. Bunazosin (10(-7) M) blocked norepinephrine-induced contraction with a parallel shift of the dose-response curve in both directions (pA2: 8.76 +/- 0.15; pA2: 8.90 +/- 0.08, respectively). 4. Serial sections of prostates were also evaluated by autoradiography. The binding sites were diffusely distributed in the interstitium. 5. We concluded that bunazosin affects multidirectional contraction in prostates.

摘要

在体外研究了α1肾上腺素受体阻滞剂布那唑嗪对去甲肾上腺素诱导的人前列腺增生组织收缩的影响。2. 前列腺标本在去甲肾上腺素浓度为10(-4)M时，沿尿道纵向和周向显示出最大收缩。3. 布那唑嗪（10(-7)M）可阻断去甲肾上腺素诱导的收缩，剂量反应曲线在两个方向均平行移动（pA2分别为8.76±0.15和8.90±0.08）。4. 还用放射自显影术对前列腺连续切片进行了评估。结合位点在间质中呈弥漫性分布。5. 我们得出结论，布那唑嗪影响前列腺的多向收缩。