Ferreiro J A
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn.
Oral Surg Oral Med Oral Pathol. 1994 Dec;78(6):761-5. doi: 10.1016/0030-4220(94)90093-0.
Canalicular adenoma is a newly recognized salivary gland adenoma that may be confused with malignant salivary gland tumors. To better characterize this neoplasm, six examples were investigated with a panel of immunohistochemistry antibodies including anti-keratin (AE1/AE3), anti-epithelial membrane antigen, anti-carcinoembryonic antigen, anti-vimentin, anti-S-100, anti-muscle specific actin, and anti-glial fibrillary acid protein. All canalicular adenomas stained in a similar fashion showing positive staining with anti-keratin, anti-vimentin, and anti-S-100 (6 of 6 cases each). Rare focal staining with anti-epithelial membrane antigen and anti-glial fibrillary acid protein was noted (1 of 6 cases each). This immunohistochemistry staining pattern was compared with those of ameloblastoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. Immunohistochemistry may be useful in the distinction of canalicular adenoma from other salivary gland tumors.
导管腺瘤是一种新发现的唾液腺腺瘤，可能会与唾液腺恶性肿瘤相混淆。为了更好地描述这种肿瘤，我们用一组免疫组织化学抗体对6个病例进行了研究，这些抗体包括抗角蛋白（AE1/AE3）、抗上皮膜抗原、抗癌胚抗原、抗波形蛋白、抗S-100、抗肌肉特异性肌动蛋白和抗胶质纤维酸性蛋白。所有导管腺瘤的染色方式相似，均显示抗角蛋白、抗波形蛋白和抗S-100呈阳性染色（各6例中的6例）。注意到抗上皮膜抗原和抗胶质纤维酸性蛋白有罕见的局灶性染色（各6例中的1例）。将这种免疫组织化学染色模式与成釉细胞瘤、多形性低度腺癌和腺样囊性癌的染色模式进行了比较。免疫组织化学在鉴别导管腺瘤与其他唾液腺肿瘤方面可能有用。
