Bergman R, Lichtig C, Moscona R A, Friedman-Birnbaum R
Department of Dermatology, Rambam Medical Center, Haifa, Israel.
Am J Dermatopathol. 1991 Apr;13(2):162-8. doi: 10.1097/00000372-199104000-00010.
We performed an immunohistochemical study that compared a primary adenoid cystic carcinoma (ACC) of the skin with two salivary gland ACC. All three tumors stained positively and in identical fashion for epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), broad-spectrum keratins, and low-molecular-weight keratins. Both EMA and CEA were localized to the luminal surfaces and the secreted contents of the tubular structures and the ductlike structures of the cribriform formations. The staining reactions for both types of keratin were more intense in the cells lining the tubular structures and the ductlike structures of the cribriform formations. One of the two salivary ACCs stained positively for S-100 protein; the other was positive for vimentin. The cutaneous ACC was negative for both antigens. Leu-7 antigen was not detected in either type of ACC. These results show that primary cutaneous ACC and salivary ACC have similar immunohistochemical staining patterns for a number of antigens. We believe this similarity is due to the fact that these antigens are shared by the sweat glands and salivary glands, which are considered to be the respective sites of origin for these two types of tumors.
我们进行了一项免疫组织化学研究，将皮肤原发性腺样囊性癌（ACC）与两种唾液腺ACC进行比较。所有三种肿瘤上皮膜抗原（EMA）、癌胚抗原（CEA）、广谱角蛋白和低分子量角蛋白染色均呈阳性且方式相同。EMA和CEA均定位于筛状结构的管状结构和导管样结构的腔面及分泌内容物。两种角蛋白的染色反应在筛状结构的管状结构和导管样结构内衬细胞中更强。两种唾液腺ACC中的一种S-100蛋白染色呈阳性；另一种波形蛋白呈阳性。皮肤ACC这两种抗原均为阴性。两种类型的ACC均未检测到Leu-7抗原。这些结果表明，原发性皮肤ACC和唾液腺ACC在多种抗原方面具有相似的免疫组织化学染色模式。我们认为这种相似性是由于这些抗原为汗腺和唾液腺所共有，而汗腺和唾液腺被认为分别是这两种肿瘤的起源部位。
