Socaciu C, Baba A I, Rotaru O
Department of Biochemistry, University of Agricultural Sciences, Cluj-Napoca, Romania.
Vet Hum Toxicol. 1994 Dec;36(6):535-9.
The acute and subchronic oral toxicities of 4 organotin derivatives were investigated in chickens. The LD50 values oscillated between 200 and 400 mg/kg bw and revealed a moderate or weak toxicity. Subchronic dosing with 2 doses from each compound at 2 and 10 mg/kg bw induced dose-dependent lesions seen at necropsy and histologic examinations. Involution of the thymus and bursa Fabricius, fatty degeneration of the liver, and nephrotic syndromes were the most evident effects. The butyltin derivatives induced more drastic lesions than did the phenyltins.
研究了4种有机锡衍生物对鸡的急性和亚慢性经口毒性。半数致死剂量（LD50）值在200至400毫克/千克体重之间波动，显示出中等或较弱的毒性。以2毫克/千克体重和10毫克/千克体重的剂量对每种化合物进行亚慢性给药，在尸检和组织学检查中发现了剂量依赖性病变。胸腺和法氏囊退化、肝脏脂肪变性和肾病综合征是最明显的影响。丁基锡衍生物比苯基锡衍生物引起的病变更严重。
