Elliott J R, Urban B W
Department of Anatomy & Physiology, The University, Dundee, UK.
Eur J Anaesthesiol. 1995 Jan;12(1):41-50.
The effects of low and clinically relevant concentrations of inhalation anaesthetics and related compounds on the firing behaviour of nerve axons from a number of species are described. The observation of substantial, if sometimes transient, changes in excitability is contrasted with the view that axonal ion channels are insensitive to many general anaesthetics. Taking the squid giant axon as a well-studied example, we show that a full understanding of these effects can only be achieved through a detailed investigation of the actions of a range of compounds on a number of ion channels. Small alterations in the properties of individual channel types can in combination result in major changes in the behaviour of a multi-channel system such as an axon. Finally, as an example of the spectrum of activity of structurally related compounds, we compare the effects of inhalation anaesthetics with those of volatile convulsants.
本文描述了低浓度及临床相关浓度的吸入麻醉剂和相关化合物对多种物种神经轴突放电行为的影响。兴奋性出现显著变化（有时是短暂变化）这一观察结果，与轴突离子通道对许多全身麻醉剂不敏感的观点形成对比。以研究充分的鱿鱼巨轴突为例，我们表明，只有通过详细研究一系列化合物对多种离子通道的作用，才能全面理解这些影响。单个通道类型特性的微小改变，合在一起可能会导致多通道系统（如轴突）行为的重大变化。最后，作为结构相关化合物活性谱的一个例子，我们比较了吸入麻醉剂和挥发性惊厥剂的作用效果。
