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本文引用的文献

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A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding.β2整合素CR3（CD11b/CD18）A结构域中的一个新型二价阳离子结合位点对于配体结合至关重要。
Cell. 1993 Mar 26;72(6):857-67. doi: 10.1016/0092-8674(93)90575-b.
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Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.埃可病毒1型和8型的感染取决于人类VLA-2的α2亚基。
J Virol. 1993 Nov;67(11):6847-52. doi: 10.1128/JVI.67.11.6847-6852.1993.
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Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.嵌合ICAM-1/免疫球蛋白分子对鼻病毒的高效中和与破坏作用。
J Virol. 1993 Jun;67(6):3561-8. doi: 10.1128/JVI.67.6.3561-3568.1993.
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Functional interaction between the integrin antagonist neutrophil inhibitory factor and the I domain of CD11b/CD18.整联蛋白拮抗剂中性粒细胞抑制因子与CD11b/CD18的I结构域之间的功能相互作用。
J Biol Chem. 1994 Oct 21;269(42):26419-23.
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I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.β2整合素淋巴细胞功能相关抗原-1的I结构域包含与配体细胞间黏附分子-1的结合位点。
J Biol Chem. 1994 Apr 29;269(17):12395-8.
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The I domain is essential for echovirus 1 interaction with VLA-2.I结构域对于1型艾柯病毒与VLA-2的相互作用至关重要。
Cell Adhes Commun. 1994 Oct;2(5):455-64. doi: 10.3109/15419069409004455.
7
The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms.整合素VLA-2通过不同机制结合1型艾柯病毒和细胞外基质配体。
J Clin Invest. 1993 Jul;92(1):232-9. doi: 10.1172/JCI116555.
8
Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).β2整合素CR3（CD11b/CD18）中补体iC3b结合位点的鉴定
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10680-4. doi: 10.1073/pnas.91.22.10680.
9
Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner.胶原蛋白以不依赖二价阳离子的方式直接与整合素α2β1（VLA-2，CD49b/CD29）的I结构域结合。
J Biol Chem. 1994 Oct 21;269(42):26006-10.
10
Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.重组CD11b/CD18整合素I结构域的差异配体结合特异性
J Biol Chem. 1994 Jun 24;269(25):17075-9.

肠道病毒1与分离出的VLA - 2 I结构域的相互作用

Echovirus 1 interaction with the isolated VLA-2 I domain.

作者信息

King S L, Cunningham J A, Finberg R W, Bergelson J M

机构信息

Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

J Virol. 1995 May;69(5):3237-9. doi: 10.1128/JVI.69.5.3237-3239.1995.

DOI:10.1128/JVI.69.5.3237-3239.1995
PMID:7535868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189033/
Abstract

The isolated I domain of the integrin VLA-2, produced as a bacterial fusion protein, specifically bound echovirus 1 and prevented virus attachment to cells. These results demonstrate that the receptor structures critical for virus attachment are contained solely within the VLA-2 I domain and that soluble receptor fragments are capable of preventing infection.

摘要

作为细菌融合蛋白产生的整合素VLA-2的分离I结构域，特异性结合艾柯病毒1并阻止病毒附着于细胞。这些结果表明，病毒附着所必需的受体结构仅包含在VLA-2 I结构域内，并且可溶性受体片段能够阻止感染。