Rajagopal U, Friedman R M, Robinson J B, Rohrich R J
Department of Surgery, University of Texas Southwestern Medical Center at Dallas, USA.
Plast Reconstr Surg. 1995 Apr;95(5):884-7.
Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no apparent side effects were noted.
伊洛前列素，一种稳定的前列环素类似物，能显著提高大鼠轴型腹股沟皮瓣在缺血再灌注后的存活率。在经历8小时缺血期后7天，接受治疗的皮瓣有超过90%的面积存活，而用生理盐水治疗的对照组皮瓣仅有20%的面积存活（p = 0.002）。在低剂量（10 ng/kg）时即可观察到这种效果，且未发现明显的副作用。
