Singer G G, Carrera A C, Marshak-Rothstein A, Martínez C, Abbas A K
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Curr Opin Immunol. 1994 Dec;6(6):913-20. doi: 10.1016/0952-7915(94)90013-2.
Proteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death in lymphocytes. In this article we review the recent elucidation of the role of the Fas-FasL interactions in the maintenance of tolerance to self antigens and in the homeostatic regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in Fas- and FasL-deficient mutant mouse strains.
fas基因和fas配体（fasL）基因编码的蛋白质参与淋巴细胞的凋亡性细胞死亡。在本文中，我们综述了Fas-FasL相互作用在维持对自身抗原的耐受性以及淋巴细胞克隆扩增的稳态调节中的作用的最新阐释，并讨论了Fas和FasL缺陷型突变小鼠品系中的自身免疫机制。
