[丹参酮对博莱霉素诱导的大鼠肺纤维化组织学变化及脂质过氧化物和羟脯氨酸产生的影响]
[Effects of tanshionone to bleomycin induced pulmonary fibrosis of rats on histological changes and production of lipid peroxides and hydroxyproline].
作者信息
Wang C M, He Q Z, Zhang R X
机构信息
Department of Respiratory Medicine, Affiliated Hospital Guilin Medical College.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 1994 Oct;17(5):308-10, 320.
Study was designed to explore the effect of sodium tanshionone IIA sulfonate on bleomycin-induced pulmonary fibrosis in rat. The amount of lipid peroxides (LPO), hydroxyproline in rat lung tissue homogenate was determined at 3, 7, 14, 28 day after administration respectively. The results suggest that the amount of LPO, hydroxyproline of rat lung homogenate were significantly decreased in sodium tanshionone IIA sulfonate group. In addition, histological changes and width of alveolar septa and percentage area of pulmonary fibrosis scars was measured. The results show that sodium tanshionone IIA sulfonate could ameliorate bleomycin induced pulmonary fibrosis in rat. The mechanism that sodium tanshionone IIA sulfonate could prevent and treat bleomycin-induced pulmonary fibrosis in rat was discussed.
本研究旨在探讨丹参酮IIA磺酸钠对博莱霉素诱导的大鼠肺纤维化的影响。分别于给药后3、7、14、28天测定大鼠肺组织匀浆中脂质过氧化物（LPO）、羟脯氨酸的含量。结果表明，丹参酮IIA磺酸钠组大鼠肺匀浆中LPO、羟脯氨酸含量显著降低。此外，测量了组织学变化、肺泡间隔宽度及肺纤维化瘢痕面积百分比。结果显示，丹参酮IIA磺酸钠可改善博莱霉素诱导的大鼠肺纤维化。探讨了丹参酮IIA磺酸钠防治博莱霉素诱导的大鼠肺纤维化的机制。
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