Yu J R, Qiu Z X, Yang H
Department of Medicine, First Hospital, Beijing Medical University.
Zhonghua Nei Ke Za Zhi. 1994 Sep;33(9):590-2.
By using two colour flow cytometric analysis, we examined the proportion of B lymphocytes bearing CD5 surface antigen (CD5+B cell). The level of CD5+B cells was markedly increased in active chronic ITP and active hyperthyroid patients with Graves' disease. There was an inverse correlation between the percentage of circulating CD5+B cells and platelet counts, and a positive correlation between the level of CD5+B cells in peripheral blood and serum T3 level. These results suggested that the level of CD5+B cells might play a role in producing autoantibodies in some autoimmune diseases.
通过双色流式细胞术分析，我们检测了携带CD5表面抗原的B淋巴细胞（CD5+B细胞）的比例。在活动性慢性免疫性血小板减少性紫癜（ITP）患者以及患有格雷夫斯病的活动性甲状腺功能亢进患者中，CD5+B细胞水平显著升高。循环CD5+B细胞百分比与血小板计数呈负相关，外周血中CD5+B细胞水平与血清T3水平呈正相关。这些结果表明，CD5+B细胞水平可能在某些自身免疫性疾病中自身抗体的产生过程中发挥作用。
