Fredj-Reygrobellet D, Hristova D L, Ettaiche M, Meddahi A, Jozefonwicz J, Barritault D
School of Medicine, Nice, France.
Ophthalmic Res. 1994;26(6):325-31. doi: 10.1159/000267497.
Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ulcer on the rabbit eye and compared with the activity of basic fibroblast growth factors (bFGF) added alone or in association with CMDBS. Total reepithelization was observed with bFGF + CMDBS, bFGF alone and CMDBS alone after, respectively, 3.8 +/- 0.78, 4.3 +/- 0.67 and 4.4 +/- 0.51 days. All treatments were efficient if compared with eyes treated with saline (p < 0.0001). The grade of significance of the applied treatments was as follows: bFGF + CMDBS > bFGF > CMDBS > saline. Our study pinpoints that some specific CMDBS are as potent agents as bFGF for corneal ulcer healing, and can therefore be proposed for therapeutic use.
可溶性葡聚糖聚合物衍生物（CMDBSs）最初是作为类肝素血浆代用品合成的。其中一些在相互作用方面模拟肝素，并稳定、保护和促进肝素结合生长因子的作用。在兔眼角膜溃疡模型中研究了一种特定CMDBS的伤口愈合活性，并与单独添加或与CMDBS联合添加的碱性成纤维细胞生长因子（bFGF）的活性进行了比较。分别在3.8±0.78天、4.3±0.67天和4.4±0.51天后，观察到bFGF + CMDBS、单独的bFGF和单独的CMDBS均实现了完全再上皮化。与用盐水处理的眼睛相比，所有处理均有效（p < 0.0001）。所应用处理的显著程度如下：bFGF + CMDBS > bFGF > CMDBS > 盐水。我们的研究指出，一些特定的CMDBS作为角膜溃疡愈合的药物与bFGF一样有效，因此可推荐用于治疗。
